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Season Two
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Sunday, July 20, 2008 SEARCH  
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Alzheimer's Disease

Alzheimer's Association
http://www.alz.org/

Mayo Clinic: Alzheimer's
http://www.mayoclinic.com/health/alzheimers/AZ99999

National Institute on Aging
http://www.nia.nih.gov/alzheimers

Alzheimer's Disease International
http://www.alz.co.uk/

Alzheimer's Foundation of America
http://www.alzfdn.org/index.shtml

10 Warning Signs:
How do you know if you or someone you love might have Alzheimer’s disease? Know these warning signs. If you have concerns, talk with your doctor.

1) Has trouble at work; gets mixed up about long-time jobs or hobbies.
2) Has problems thinking clearly; doesn’t use common sense; can’t make change or balance a checkbook.
3) Can’t think of the right word—a common word used every day.
4) Begins misplacing things like mail, bills, glasses, tools.
5) Doesn’t have any interest in being active; just sits around.
6) Changes in personality; for example, an easy-going person gets angry often.
7) Does strange things like going outside without a coat in freezing weather or giving money unexpectedly to strangers.
8) Cries for no reason or is sad frequently.
9) Can’t do everyday things like getting dressed alone.
10) Doesn’t recognize familiar people, places or things.

 

Alzheimer’s Disease Facts (from the Alzheimer's Association):

  • Alzheimer’s disease is a disease of the brain that causes a steady decline in memory. This results in dementia–a loss of thinking, remembering and reasoning severe enough to interfere with everyday life. Alzheimer’s is the most common form of dementia.
  • Alzheimer’s is the fourth-leading cause of death among adults in the United States, behind heart disease, cancer and stroke.
  • People age 65 and older have a 10 percent chance of developing Alzheimer’s disease. At age 85, that risk increases to 50 percent.
  • Nationally, more than 4.5 million Americans have Alzheimer’s disease. By 2050, that number will increase to 16 million unless a treatment or prevention is found.
  • Missouri faces an 18% increase in the number of cases of Alzheimer's disease between 2000 and 2025.
  • The disease process typically lasts an average of eight years, but can last as long as 20. The average lifetime cost of Alzheimer’s disease, per person, is $174,000.
  • Families contribute the bulk of care for their loved ones with Alzheimer’s disease: the estimated value of this informal caregiving is $257 billion – far more than the $32 billion cost of paid home health care and the $92 billion cost of nursing home care.
  • Almost 75 percent of Alzheimer’s caregiving is done by family members. Seven in 10 people with Alzheimer’s disease live at home. The average annual cost of paid care for people with Alzheimer’s disease at home is $19,000.
  • It is estimated that Alzheimer’s disease cost American business $61 billion. Of that figure, $24.6 billion is Alzheimer health care costs, and $36.5 billion is related to caregiver’s lost productivity, absenteeism and worker replacement.
  • Nearly 60% of all nursing home residents have Alzheimer’s disease or another dementia. The average annual cost of Alzheimer nursing home care is $64,000.
  • If annual research funding of $1 billion for the next five years resulted in modest delays in onset and slowing of progression by 2010, the return on investment in 2015 could be as high as $13 for each federal dollar spent on research. This type of advancement could translate into:
    --$51 billion in Medicare savings by 2015
    --$10 billion in Medicaid saving by 2015

Progress in Alzheimer Research:
The investment made by Congress has paid off. The goal of a world without Alzheimer’s is clearly within reach. Dramatic progress has been seen in the following areas:
  • Diagnosis – we can now diagnose Alzheimer's with over 90% accuracy
  • Genetics – we have discovered genes involved in early-onset Alzheimer's disease and identified the first well-confirmed susceptibility gene (APOE) as a major risk factor for late-onset Alzheimer's.
  • Understanding the Disease Process – scientists have a more detailed understanding of abnormal protein changes involved in the death of brain cells, and possible strategies for blocking and reversing those changes.
  • Prevention – There is growing evidence suggesting that lifestyle, including maintaining a healthy diet, remaining physically and socially active and controlling weight and cholesterol, may help to maintain cognitive function throughout the aging process.
  • Treatment – There are now five FDA approved drug therapies, with more compounds in the pipeline that may modify the disease process to delay the onset of illness and extend quality of life for affected individuals and their caregivers.
  • Imaging - Researchers have developed the first compound that highlights abnormal Alzheimer protein deposits in patients undergoing a positron emission tomography (PET) brain scan.


An Investment of $1 billion Annually is Needed to Build on the Progress Made
Despite the recent progress in Alzheimer's research, the underlying cause still remains a mystery and additional work is needed to develop better methods of treating and eventually preventing the disease. If current federal funding for Alzheimer's research were increased to $1 billion annually, substantial progress can be made on the most promising leads. These resources are needed to:

  • Identify New Targets for Preventing Alzheimer’s
  • Identify and Understand Risk Factors
  • Detect Alzheimer’s Before it Ravages the Brain
  • Conduct Basic Science Research


Alzheimer’s Association, St. Louis Chapter Facts:

  • An estimated 66,000 people have AD in the 38-county service area in eastern Missouri and nearby Illinois served by the association. Each person with the disease has typically has 1-3 caregivers so the disease could impact as many as 264,000 persons in our service area.
  • Eighty five cents of every dollar contributed to the Alzheimer’s Association directly supports local programs and services.
  • The Alzheimer's Association has granted nearly $185 million in research grants since 1982. In the last five years, the St. Louis chapter alone has donated more the $1.3 million to research—both locally and nationally.
  • More than 90% of financial support for the chapter comes from the local communities that we serve.